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March 1992

In Vitro Modulation of Human Laryngeal Papilloma Cell Differentiation by Retinoic Acid

Author Affiliations

San Diego, Calif

Arch Otolaryngol Head Neck Surg. 1992;118(3):235-236. doi:10.1001/archotol.1992.01880030017004

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Researchers at the Long Island Jewish Medical Center, New York, NY, have recently developed an in vitro model to study the growth of human laryngeal papilloma cells at an air-liquid interface and for determining the effects of various agents. The model permits growth of human laryngeal papilloma cells sustained on a collagen matrix in tissue culture to form stratified squamous epithelium when exposed to an air-liquid interface. In their work reported at the annual meeting of the American Academy of Otolaryngology—Head and Neck Surgery in Kansas City, Mo, Angelo Reppucci, MD, Teresa Dilorenzo, MA, Alan Abramson, MD, and Bettie Steinberg, PhD, presented the effects of retinoic acid in this system. At low concentrations of retinoic acid (10−9 mol/L and 10−8 mol/L), the cells formed a stratified squamous epithelium with a differentiation-specific protein stain

Section Editor.Darrell Hunsaker, MD, San Diego, Calif ing pattern identical to that found

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