[Skip to Navigation]
April 1992

The Effect of the Inhalational Anesthetic Combination, Isoflurane and Nitrous Oxide, on Survival of a Random Skin Flap in a Pig

Author Affiliations

San Diego, Calif

Arch Otolaryngol Head Neck Surg. 1992;118(4):364. doi:10.1001/archotol.1992.01880040018003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


At the 1991 annual meeting of the American Academy of Otolaryngology—Head and Neck Surgery in Kansas City, Mo, Joseph E. Dohar and his coworkers, George Goding and Robert Maisel, Minneapolis, Minn, presented their results using isoflurane and nitrous oxide on survival of a random skin flap in a pig. Their study attempted to assess the pharmacologic properties of various inhalational anesthetics on random skin flaps. The authors previously demonstrated that isoflurane enhances survival in a random skin flap relative to nitrous oxide and a control. In this particular set of experiments, these researchers were interested in studying the effects of combining isoflurane and nitrous oxide. Dorsallybased random skin flaps were raised in 21 pigs, and the mean area skin flap survival was determined. The largest surface area of survival was associated with the administration of isoflurane alone (79.4%), and the smallest surface area of survival was associated with the administration

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution