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August 1992

Ameloblastoma of the Mandible With Intracranial Metastasis: A Case Study

Author Affiliations

From the Departments of Otolaryngology (Drs Phillips and Mattox), Dermatology (Dr Corio), and Neurosurgery (Dr Brem), The Johns Hopkins School of Medicine, Baltimore, Md.

Arch Otolaryngol Head Neck Surg. 1992;118(8):861-863. doi:10.1001/archotol.1992.01880080083018

• Ameloblastoma is an aggressive locally recurring neoplasm of odontogenic epithelium. We describe a case of a mandibular ameloblastoma with a 17-year history of local recurrences followed by two metachronous intracranial metastases. Central nervous system metastasis without pulmonary involvement is previously unreported in a living patient with ameloblastoma. The behavior of this tumor qualifies it as a malignant ameloblastoma.

(Arch Otolaryngol Head Neck Surg. 1992;118:861-863)