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December 1992

Cytogenetic Alterations in Laryngeal Carcinomas

Author Affiliations

From the Institute of Otorhinolaryngology—University of Catania (Drs Allegra, Garozzo, and Catalano) and the Laboratory of Human Genetics (Dr Grillo), Catania, Italy.

Arch Otolaryngol Head Neck Surg. 1992;118(12):1320-1322. doi:10.1001/archotol.1992.01880120046009

• The purpose of this study was to determine the most frequent chromosomal abnormalities in laryngeal carcinomas. Biopsy specimens of surgical resections from laryngeal squamous cell carcinomas from 15 patients representing different degrees of histologic differentiation were analyzed in short-term culture. Nine of the 15 tumors were hypodiploid with 41 to 45 chromosomes, and four of the 15 tumors were polyploid with more than 50 chromosomes. The most frequent chromosomal alterations we noted included deletion of the short arm of chromosome 3 in 60%, monosomy of chromosome 11 in 30%, and inversions of chromosome 9 and 16 that were present in 20% of the cases.

(Arch Otolaryngol Head Neck Surg. 1992;118:1320-1322)

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