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In Reply.—I appreciate the opportunity to respond to the letter by Gallo and coworkers that was in response to our article that appeared in the January issue of the Archives. Their letter suggests that advanced head and neck cancers produce significant interleukin-6 serum levels which produce systemic responses, including acute-phase proteins as well as other secondary cytokines. In agreement with this concept, the burgeoning evidence in head and neck immunology, as well as molecular immunology, supports that tumors produce multiple secondary cytokines as well as other paracrine-secreted substances. Recent work in our laboratory has shown that squamous cell carcinoma cell lines demonstrate messenger RNA expression and secondary cytokine production of interleukin 1α and interleukin 6, as well as TGF-β. Additionally, the interaction of tumor cells, tumor-associated lymphocytes, tumor fibroblastic matrix, and other tumor microenvironment pleuripotential cells all may act in a very complex interactive manner. Such questions are being
CLAYMAN GL. Acute-Phase Proteins and Interleukin 6 Serum Level in Head and Neck Cancer-Reply. Arch Otolaryngol Head Neck Surg. 1992;118(12):1366–1367. doi:10.1001/archotol.1992.01880120092020
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