• Since 1985, a number of reports have highlighted the effectiveness of a short course of sulfamethoxazole-trimethoprim as an adjuvant to immunosuppressive drugs in the treatment of Wegener's granulomatosis. We report our experience with long-term sulfamethoxazole-trimethoprim therapy in patients with Wegener's granulomatosis. We describe recent advances in the pathogenesis of Wegener's granulomatosis, suggest a complementary mechanism of action of sulfamethoxazole-trimethoprim, and advocate long-term sulfamethoxazole-trimethoprim therapy as a treatment option in Wegener's granulomatosis.
(Arch Otolaryngol Head Neck Surg. 1993;119:103-105)
McRae D, Buchanan G. Long-term Sulfamethoxazole-Trimethoprim in Wegener's Granulomatosis. Arch Otolaryngol Head Neck Surg. 1993;119(1):103–105. doi:10.1001/archotol.1993.01880130105015
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