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January 1993

Long-term Sulfamethoxazole-Trimethoprim in Wegener's Granulomatosis

Author Affiliations

From the Ear, Nose, and Throat Department, Southend Hospital, Westcliff-on-Sea, England. Dr McRae is now with the Ear, Nose, and Throat Department, The Royal London (England) Hospital.

Arch Otolaryngol Head Neck Surg. 1993;119(1):103-105. doi:10.1001/archotol.1993.01880130105015

• Since 1985, a number of reports have highlighted the effectiveness of a short course of sulfamethoxazole-trimethoprim as an adjuvant to immunosuppressive drugs in the treatment of Wegener's granulomatosis. We report our experience with long-term sulfamethoxazole-trimethoprim therapy in patients with Wegener's granulomatosis. We describe recent advances in the pathogenesis of Wegener's granulomatosis, suggest a complementary mechanism of action of sulfamethoxazole-trimethoprim, and advocate long-term sulfamethoxazole-trimethoprim therapy as a treatment option in Wegener's granulomatosis.

(Arch Otolaryngol Head Neck Surg. 1993;119:103-105)