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February 1993


Arch Otolaryngol Head Neck Surg. 1993;119(2):246-250. doi:10.1001/archotol.1993.01880140136022

Pathologic Quiz Case 1  Martin S. Trott, MD, Thomas N. Helm, MD, Cleveland, OhioA 67-year-old woman presented to the otolaryngology clinic with a 4-month history of painful oral lesions. She denied tobacco and alcohol use. There was no history of fever, associated skin lesions, arthritis, or ocular symptoms. The patient stated that the lesions initially appeared asynchronously as friable tense blisters.Physical examination revealed multiple flaccid blisters with a grayish membrane surface located on the lips, buccal mucosa, epiglottis, and larynx (Fig 1). The tongue was not involved and no other associated skin lesions were seen. There was no adenopathy. A biopsy specimen obtained from the perilesional mucosa was sent fresh in saline for direct IgG immunofluorescence studies (Fig 2).What is your diagnosis?

Pathologic Quiz Case 2  Michael S. Panosian, MD; Arthur S. Hengerer, MD; Charlotte K Ryan, MD, Rochester, NYA 32-year-old woman was referred for a

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