To the Editor.—I would like to comment on the article by Shikani et al.1 On page 523, Fig 2 is an illustration of an untreated nude mouse 90 days after subcutaneous transplantation of squamous cell carcinoma. The mouse has a massive tumor that may be large enough to cause pain and/or discomfort to the animal. The photograph of the animal is graphic enough to pro
BROWN OE. Animal Research. Arch Otolaryngol Head Neck Surg. 1993;119(7):798–799. doi:10.1001/archotol.1993.01880190094021
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