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June 1994

Increasing Evidence That the Myoepithelial Cell Is the Actual Ancestor of Pleomorphic Adenoma of the Salivary Gland

Author Affiliations

Florence, Italy

Arch Otolaryngol Head Neck Surg. 1994;120(6):675. doi:10.1001/archotol.1994.01880300089017

We read the article by Witsell and coworkers1 that appeared in the October issue of the Archives with great interest. In that article the authors describe the establishment of a new cell strain, named UNC4, from a human benign pleomorphic adenoma, and describe its immunocytochemical and cytogenetic features that are consistent with the myoepithelial nature of the cells. These features closely parallel our previously reported findings on a similar myoepithelial cell line, named PA 16/23, that arose from a human pleomorphic adenoma,2 and are in keeping with the studies by Shirasuna and coworkers,3 who first isolated a myoepithelial cell line from a pleomorphic adenoma. Taken together, the bulk of the in vitro studies strongly favor the idea that transformed myoepithelial cells are actual ancestors to pleomorphic adenomas. It seems feasible that the unique histopathologic features of pleomorphic adenomas, in which stromal and epithelial areas coexist, thus justifying

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