A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.
(Arch Otolaryngol Head Neck Surg. 1994;120:1273-1276)
Doyle DJ, Henderson LA, LeJeune FE, Miller RH. Changes in Human Papillomavirus Typing of Recurrent Respiratory Papillomatosis Progressing to Malignant Neoplasm. Arch Otolaryngol Head Neck Surg. 1994;120(11):1273–1276. doi:10.1001/archotol.1994.01880350079014