To determine the role of genetic predisposition in the etiology of head and neck squamous cell carcinoma.
The outpatient clinics of the departments of otorhinolaryngology and maxillofacial surgery.
First-degree relatives of patients with new head and neck cancer, with first-degree relatives of the patients' spouses as controls.
Main Outcome Measure:
Occurrence of cancer of the respiratory and upper digestive tract in relatives of patients with head and neck cancer and controls.
First-degree relatives (n=617) of 105 patients with head and neck cancer had 31 cases of cancer of the respiratory and upper digestive tract vs 10 cases in the control group (n=618) (relative risk, 3.5; P=.0002). This higher rate of cancer was even larger in siblings (16 vs 2, relative risk, 14.6; P=.0001).
Genetic predisposition is an important risk factor for squamous cell carcinoma of the head and neck.(Arch Otolaryngol Head Neck Surg. 1995;121:157-160)
Copper MP, Jovanovic A, Nauta JJP, et al. Role of Genetic Factors in the Etiology of Squamous Cell Carcinoma of the Head and Neck. Arch Otolaryngol Head Neck Surg. 1995;121(2):157–160. doi:10.1001/archotol.1995.01890020019005
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