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April 1995

An Assessment of Cochlear Hair-Cell Loss in Insulin-Dependent Diabetes Mellitus Diabetic and Noise-Exposed Rats

Author Affiliations

From the Division of Otolaryngology—Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill.

Arch Otolaryngol Head Neck Surg. 1995;121(4):452-456. doi:10.1001/archotol.1995.01890040074012

Objective:  The purpose of this study was to investigate if insulin-dependent diabetes mellitus causes degenerative changes in the inner ear and whether these changes are exacerbated by noise exposure.

Methods:  Insulin-dependent diabetes mellitus was induced in male rats using streptozotocin (65 mg/kg of body weight, intravenously). Half the animals were exposed to 95 dB of random noise for 12 hours per day over a period of 6 months. The cochleae were removed, fixed, decalcified, dissected, and the hair cells counted.

Results:  A significant loss of outer hair cells was exhibited in both noise-exposed groups; however, although there was no significant difference between these two groups, the noise-exposed diabetic animals had significant loss in more turns than did the noise-exposed control animals. The diabetic animals were not statistically different from the control animals.

Conclusion:  These results suggest that insulin-dependent diabetes mellitus may increase the hair-cell loss caused by noise overstimulation.(Arch Otolaryngol Head Neck Surg. 1995;121:452-456)