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July 1995

Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991

Author Affiliations

From the Division of Head and Neck Surgery, School of Medicine, University of California—Los Angeles.

Arch Otolaryngol Head Neck Surg. 1995;121(7):778-782. doi:10.1001/archotol.1995.01890070064014

Objective:  To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients.

Design:  Retrospective review of biopsy specimens recorded as amyloidosis.

Setting:  Tertiary care referral center serving a diverse patient base.

Patients:  Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations.

Outcome Measures:  Good functional outcome and survival of patients with amyloidosis.

Results:  The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis.

Conclusion:  Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease.(Arch Otolaryngol Head Neck Surg. 1995;121:778-782)

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