Thank you for the opportunity to respond to the letters concerning our article in the Archives entitled, "The Human Adenoid: a Morphologic Study." We are perplexed by the apparent difficulties regarding the discovery of the M cells in the nasopharyngeal tonsil. In 1984, Karchev and Kabakchiev1 first described the presence of M cells and intraepithelial lymphocytes by transmission electron microscopy. They suggested that the M cells were key cells for the immunogenesis of the nasopharyngeal tonsil.
In our article, we cited their work and clearly described what they reported. All of our figures are original and not copies of the work by Karchev and Kabakchiev as Konstantinov and Golemanov appear to suggest. In 1989, Fujiyoshi et al,2 in an article we were unaware of at the time ours was published, studied several functional aspects of the nasopharyngeal tonsil that included uptake of horseradish peroxidase by nonciliated cells in
Innes DJ, Winther B. The Human Adenoid-Reply. Arch Otolaryngol Head Neck Surg. 1995;121(7):816. doi:10.1001/archotol.1995.01890070102029
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