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March 1996

A Prospective, Double-blind, Randomized Study of the Effects of Perioperative Steroids on Palatoplasty Patients

Arch Otolaryngol Head Neck Surg. 1996;122(3):267-270. doi:10.1001/archotol.1996.01890150045008

Objective:  To determine whether perioperative steroids affect the outcome of patients who undergo palatoplasty.

Design:  A prospective, double-blind, randomized study.

Setting:  A university medical center.

Patients:  Twenty patients undergoing primary repair of a cleft palate.

Intervention:  A prospective double-blind technique was used to randomly assign patients to receive a placebo or dexamethasone sodium phosphate perioperatively.

Main Outcome Measure:  Patients were monitored for postoperative airway distress, fever, oral fluid intake, days of hospitalization, and wound healing.

Results:  The use of perioperative steroids was associated with shorter hospitalizations. No adverse sequelae from the administration of steroids were identified.

Conclusion:  In our current managed care environment, the use of perioperative steroids may play an important role in reducing health care costs.(Arch Otolaryngol Head Neck Surg. 1996;122:267-270)