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Article
May 1996

Radiation-Induced Malignant Fibrous Histiocytoma in Patients With Nasopharyngeal Carcinoma

Author Affiliations

From the Departments of Otolaryngology (Drs Ko and Hsu), Pathology (Dr Chen), and Radiotherapy (Dr Lui), National Taiwan University Hospital, Taipei.

Arch Otolaryngol Head Neck Surg. 1996;122(5):535-538. doi:10.1001/archotol.1996.01890170067013
Abstract

Objective:  To evaluate the prevalence, 15-year cumulative incidence, time interval, and prognosis of radiation-induced malignant fibrous histiocytoma of the head and neck in long-term survivors of nasopharyngeal carcinoma.

Design:  Cohort.

Setting:  Tertiary care hospital.

Patients:  Eight long-term survivors of nasopharyngeal carcinoma with malignant fibrous histiocytoma in the maxillary sinus or nasal cavity.

Main Outcome Measurement:  Survival of postirradiation malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma.

Results:  The prevalence of radiation-induced malignant fibrous histiocytoma in long-term survivors of nasopharyngeal carcinoma was 0.38%. The 15-year cumulative incidence was 2.2%. Most tumors occurred in the maxillary sinus and were characterized by spindleshaped tumor cells with plump nuclei arranged in a whorl or storiform pattern in a fibrous stroma. The mean interval between malignant fibrous histiocytoma and nasopharyngeal carcinoma was 121 months. Local recurrence developed in all cases within 9 months after surgery. Six patients died of disease without distant metastasis within 30 months. Two patients were alive with disease for 10 and 32 months, respectively.

Conclusions:  Radiation-induced malignant fibrous histiocytoma in the head and neck region in long-term survivors of nasopharyngeal carcinoma is rare. It takes a long time to occur after irradiation and is locally invasive with poor prognosis.(Arch Otolaryngol Head Neck Surg. 1996;122:535-538)

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