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Article
December 1996

Dynamics of Soluble Adhesion Molecule Levels in Patients With Pollinosis

Arch Otolaryngol Head Neck Surg. 1996;122(12):1398-1400. doi:10.1001/archotol.1996.01890240104023
Abstract

Objectives:  To define the dynamics of systemic and local soluble adhesion molecule levels and to discuss the role of these molecules in the pathogenesis of allergic rhinitis.

Design:  Randomized control trial.

Subjects:  Twelve volunteers with Japanese cedar pollinosis and 7 healthy volunteers.

Interventions:  The levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selectin, and soluble L-selectin in serum samples and nasal epithelial lining fluids (ELF) from 12 patients with pollinosis were measured 5 times throughout the allergy preseason to postseason, and the results were compared with those from 7 healthy subjects.

Results:  The levels of sICAM-1 (P<.05) and sVCAM-1 (P<.05) in sera were up-regulated, and the levels of soluble L-selectin (P<.01) in sera were down-regulated during the early stage of the season in the allergic subjects. The difference between the levels of sICAM-1 and sVCAM-1 in sera in the early and midseason was statistically significant in the allergic subjects (P<.05). The levels of sICAM-1 in ELF were up-regulated during the early and mid-season. The levels of sVCAM-1, soluble E-selectin, and soluble L-selectin in ELF were undetectably low throughout the preseason to postseason.

Conclusion:  There is evidence of the unique stage-dependent differential contributions of various soluble adhesion molecules in the pathogenesis of seasonal allergic rhinitis with a small amount of natural allergen provocation.Arch Otolaryngol Head Neck Surg. 1996;122:1398-1400

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