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Clinical Problem Solving: Pathology
March 2004

Pathology Quiz Case 2—Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2004;130(3):369-370. doi:10.1001/archotol.130.3.369

Chondrosarcoma, which is the fourth most common tumor of bone and cartilage,1 is found predominantly in the pelvis and lower skeleton; however, it occurs in the head and neck region in approximately 10% of cases.1,2 The most common sites of occurrence in the head and neck are the maxilla and the larynx.1 Laryngeal chondrosarcoma is considered to be a rare tumor, with approximately 200 to 250 cases reported in the literature.1,3,4 It is a slow-growing indolent tumor that usually presents in men (male-female ratio, 3.6-1.0)1,4 during the fifth to seventh decades of life, with the mean presentation in the sixth decade of life.1,4 As in the case described herein, the presentation commonly includes hoarseness, dysphagia, dyspnea (which can proceed to airway compromise), globus, or a painless mass.1-7 Because of the slow and frequently asymptomatic growth of the laryngeal chodrosarcoma, its average size at the time of diagnosis is approximately 3 cm.4

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