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Clinical Problem Solving: Pathology
December 2004

Pathology Quiz Case 2—Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2004;130(12):1440-1441. doi:10.1001/archotol.130.12.1440-b

Angiosarcoma is an uncommon malignant mesenchymal tumor that can occur in any region of the body. Approximately 50% of all angiosarcomas develop in the head and neck, but they account for fewer than 0.1% of all the malignant neoplasms that occur in that area.1 Cutaneous angiosarcoma commonly affects elderly white men. The estimated male-female ratio is 3:1. The median age at onset is approximately 64 years (age range, 6 months to 92 years). Although there is some suggestion that younger patients tend to do better, no studies show a statistically significant association between age and outcome.2

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