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Clinical Problem Solving: Pathology
August 2005

Pathology Quiz Case: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2005;131(8):736. doi:10.1001/archotol.131.8.736

Hepatocellular carcinoma usually metastasizes to the lungs, adrenal glands, and regional lymph nodes.1 Metastatic spread to bone is uncommon. Because the jaws do not contain any lymphatic vessels, spread to this site occurs hematogenously. Metastatic HCC to the jaws occurs most frequently in the sixth and seventh decades of life and is especially prevalent among males. Although the most common symptoms and signs are pain and swelling in the affected regions, even paresthesia of the lower lip and chin has been reported.2