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Clinical Problem Solving: Radiology
October 2005

Radiology Quiz Case 3: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2005;131(10):927. doi:10.1001/archotol.131.10.927

Olfactory neuroblastoma, or ENB, is a very rare malignant neoplasm that arises from neuroepithelial cells of the olfactory mucosa. It was first described by Berger et al1 in France in 1924 and introduced in the American literature by Schall and Lineback2 in 1951. It represents 3% of all true tumors in the nasal cavity. It has been reported in all age groups, with a slight male predominance and a bimodal age distribution, with early peaks in the second and third decades of life and a later peak in the fifth decade of life.3