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Clinical Problem Solving: Pathology
March 21, 2011

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2011;137(3):308-309. doi:10.1001/archoto.2011.21-b

Kikuchi disease, also known as Kikuchi-Fujimoto disease and Kikuchi histiocytic necrotizing lymphadenitis, is a rare, benign condition of unknown etiology. The age at onset ranges from 6 to 80 years, but the mean age in the United States is 30 years. It is more common in women than men. In 3 statistical studies in Japan, the male to female ratio was 1:4, 1:1.6, and 1:1.26, respectively.1Although the pathogenesis of Kikuchi disease is unknown, based on clinical presentation and histologic features it may involve an immune response to infection and may be associated with white blood cell dysfunction. Proposed inciting agents include Epstein-Barr virus,2human herpesvirus 6, human herpesvirus 8,2human immunodeficiency virus, paramyxovirus, parainfluenza virus, Yersinia enterocolitica, and Toxoplasma.3