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Goldstein NA, Keller R, Rey K, et al. Sleep-Disordered Breathing and Transcranial Dopplers in Sickle Cell Disease. Arch Otolaryngol Head Neck Surg. 2011;137(12):1263–1268. doi:10.1001/archoto.2011.190
Author Affiliations: Divisions of Pediatric Otolaryngology (Drs Goldstein and Keller and Messrs Dastgir and Mironov) and Pediatric Hematology (Ms Rey and Drs Rao and Miller), and Scientific Computing Center (Dr Weedon), State University of New York Downstate Medical Center, and Kings County Hospital Center (Ms Rey and Drs Rao and Miller), Brooklyn, New York.
Objectives To determine the prevalence of sleep-disordered breathing in children with sickle cell disease and whether there is an association of sleep-disordered breathing with high-risk transcranial Doppler ultrasonography (TCD) velocities.
Study Design Cross-sectional.
Setting Tertiary care academic medical center.
Patients Sixty-four children (aged 2-14 years) selected for eligible genotype (type SS or Sβ0-thalassemia) and no history of stroke.
Interventions Parents completed the Pediatric Sleep Questionnaire. Overnight polysomnography was performed for children with snoring. The TCD was performed or existing results were obtained for all children; for children who underwent transfusion therapy, readings prior to the transfusion were analyzed. Children with abnormal or conditional TCD (flow velocity ≥170 cm/s in any vessel) were considered high risk.
Main Outcome Measures Prevalence of sleep-disordered breathing and TCD velocity and frequency of high-risk TCD in patients with and without sleep-disordered breathing.
Results The prevalence of snoring was 37.5% (95% CI, 26.7%-49.8%), the prevalence of positive polysomnography findings was 23.7% (14.6%-36.1%), and the prevalence of positive Pediatric Sleep Questionnaire scores was 21.9% (13.4%-33.6%). There was no significant difference in TCD velocity or number of patients with high-risk TCD between nonsnorers and children with snoring but negative polysomnography findings and children with snoring and positive polysomnography findings (P = .91 and P = .66, respectively) or between nonsnorers and snorers with a negative Pediatric Sleep Questionnaire score and snorers with a positive Pediatric Sleep Questionnaire score (P = .76 and P = .33, respectively).
Conclusion There is a high prevalence of snoring and sleep-disordered breathing among children with sickle cell disease, but our results do not support an association with cerebrovascular risk.
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