Expression of the Transforming Growth Factor β Isoforms in Inflammatory Cells of Nasal Polyps | Otolaryngology | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
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Original Article
December 1998

Expression of the Transforming Growth Factor β Isoforms in Inflammatory Cells of Nasal Polyps

Author Affiliations

From the Departments of Oto-Rhino-Laryngology and Head and Neck Surgery (Drs Coste, Wang, and Peynegre) and Physiology (Dr Lefaucheur), Hôpital Intercommunal and Centre Hospitalo-Universitaire Henri Mondor de Créteil, Institut National de la Santé et de la Recherche Médicale, Unite U 296, Faculty of Medicine (Drs Coste and Escudier), the Department of Pediatrics, Hôpital Intercommunal de Créteil (Dr Lesprit), and Groupe d'Etudes et de Recherche sur le Muscle et le Nerf, Faculty of Medicine (Ms Poron), Université Paris XII, Créteil; and the Department of Histology, University Hospital Pitié-Salpêtriére, Université Paris VI, Paris (Dr Escudier), France.

Arch Otolaryngol Head Neck Surg. 1998;124(12):1361-1366. doi:10.1001/archotol.124.12.1361

ALTHOUGH nasal polyposis is frequently encountered in the practice of otolaryngology, its pathophysiological features are still poorly understood and it remains difficult to cure. Nasal polyposis is a chronic inflammatory disease of the upper airways in which the structural modifications of epithelium (secretory hyperplasia and squamous metaplasia) and lamina propria mucosae (basement membrane thickening, extracellular matrix accumulation, and fibrosis) are frequently associated with inflammatory cell infiltration.1 Inflammatory cells release various cytokines and growth factors that are likely to regulate other features of nasal polyposis, such as fibroblast proliferation, extracellular matrix production, and epithelial cell proliferation and/or differentiation.2 A better understanding of the mechanisms underlying these mucosal alterations and cellular interactions should help physicians design more appropriate therapeutic strategies.