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Robey TC, Välimaa T, Murphy HS, Tôrmâlâ P, Mooney DJ, Weatherly RA. Use of Internal Bioabsorbable PLGA "Finger-Type" Stents in a Rabbit Tracheal Reconstruction Model. Arch Otolaryngol Head Neck Surg. 2000;126(8):985–991. doi:10.1001/archotol.126.8.985
To design and develop a biodegradable tracheal stent that can be used internally to stabilize and support surgically reconstructed airways.
In vitro mechanical and degradative properties of 80:20 poly(D,L-lactide-co-glycolide) (PLGA) "finger-like" stents were determined. The stents were then tested in vivo in rabbits that underwent anterior patch tracheoplasties with fascia lata grafts. Comparisons were made between a control group and an internal stent group for stridor development, overall group mortality, reconstructed airway lumen size, and histological findings.
Twenty-five New Zealand white rabbits.
The average dry modulus for the internal stents was 6800 kPa. All of the internal stents cracked by 4 weeks in buffer solution. Significant mass loss was not noted in vitro until after 5 weeks in buffer solution. By 14 weeks, the stents were nearly 100% degraded. The attrition rate for the control group was 23% compared with 17% for the experimental group. The stridor rate for the control group was also higher at 38% compared with 17% for the stented group. The stented rabbits had a significantly smaller average stenosis (23%) across the entire reconstruction site than the control group (34%) (P<.05).
Biodegradable PLGA stents degrade in a predictable fashion and have a statistically significant effect in augmenting anterior patch tracheoplasties with fascia lata grafts in rabbits.
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