Influence of Prior Hyperbaric Oxygen Therapy in Complications Following Microvascular Reconstruction for Advanced Osteoradionecrosis | Critical Care Medicine | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
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Original Article
January 2003

Influence of Prior Hyperbaric Oxygen Therapy in Complications Following Microvascular Reconstruction for Advanced Osteoradionecrosis

Author Affiliations

From the Departments of Otolaryngology–Head and Neck Surgery (Drs Gal, Yueh, and Futran) and Health Services (Dr Yueh), University of Washington, and the Health Services Research and Development Service, Puget Sound Veterans Affairs Medical Center (Dr Yueh), Seattle, Wash.

Arch Otolaryngol Head Neck Surg. 2003;129(1):72-76. doi:10.1001/archotol.129.1.72
Abstract

Objective  To review surgical outcomes in the management of advanced mandibular osteoradionecrosis (ORN) with aggressive debridement and microvascular reconstruction.

Design  Retrospective cohort study.

Setting  Tertiary care referral center.

Patients  Thirty patients with Marx stage III ORN of the mandible who underwent debridement with microvascular reconstruction. Two types of patients with stage III disease were included: those who had not received prior hyperbaric oxygen (HBO) therapy but who presented with a pathologic fracture, orocutaneous fistula, or bony resorption of the inferior border of the mandible (group 1, n = 9), and those who were classified as having stage III disease as a result of failure of previous debridement and HBO therapy (group 2, n = 21).

Main Outcome Measure  Clinical resolution of ORN as well as surgical perioperative complications.

Interventions  Debridement and primary free flap reconstruction in all patients; Perioperative HBO therapy in 3 patients.

Results  The overall complication rate was 43%, but 29 (97%) of 30 patients had clinical resolution of their ORN. There were no flap failures. After smoking status and use of perioperative HBO were adjusted for, patients with Marx stage III disease who had received prior HBO therapy (group 2) were significantly more likely to have postoperative wound infection (P = .01) and overall surgical complications (P = .04) than were patients with stage III disease who had never been treated with HBO (group 1). Perioperative HBO therapy was provided too infrequently to comment on its effectiveness.

Conclusions  Microvascular reconstruction is effective in the treatment of patients with mandibular ORN. Management of mandibular ORN can be successfully achieved without the use of perioperative HBO therapy. Because only 3 patients received perioperative HBO therapy, we are unable to comment on its potential benefit. Patients in whom prior HBO therapy has failed are significantly more likely to have surgical complications than are other patients with Marx stage III disease, and further study is required to improve outcomes in this subgroup of patients.

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