Obesity as a Risk Factor for Primary Spontaneous Rhinoliquorrhea | Congenital Defects | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Original Article
March 2003

Obesity as a Risk Factor for Primary Spontaneous Rhinoliquorrhea

Author Affiliations

From the Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland. The authors have no relevant financial interest in this article.

Arch Otolaryngol Head Neck Surg. 2003;129(3):324-326. doi:10.1001/archotol.129.3.324

Objective  To determine whether obesity is a potential risk factor of primary spontaneous cerebrospinal fluid rhinorrhea (CSFR).

Design  Retrospective study.

Setting  University hospital.

Patients and Methods  The clinical data of 79 patients diagnosed with CSFR who had been treated at our hospital between 1991 and 2001 were assessed. The data of 61 (77%) of 79 cases were complete and could be used for this study. Patients were segregated according to the cause of their CSFR: 21 (34%) due to head trauma, 14 (23%) due to previous surgery, 7 (11%) due to congenital malformation, and 2 (3%) due to tumor adjacent to the anterior cranial fossa. Of the 61 subjects, 17 (28%) had CSFR without any detectable reason. This group was therefore designated as primary spontaneous CSFR. The body mass indexes (BMIs) of all patients were compared and statistically evaluated.

Results  The mean BMI (calculated as weight in kilograms divided by the square of height in meters) of the 17 patients with primary spontaneous CSFR was 34.87, which was significantly higher (P<.001) than the mean BMI of the other 44 patients (28.53). The mean BMI of the group of patients with CSFR due to previous surgery or trauma was significantly lower than the BMI of the group with primary spontaneous CSFR (P<.003), whereas in relation to the group afflicted with tumors and malformations, only a tendency (P<.28) was found.

Conclusion  Our data suggest that obese patients are at an increased risk to develop primary spontaneous CSFR.