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Jaya C, Job A, Mathai E, Antonisamy B. Evaluation of Topical Povidone-Iodine in Chronic Suppurative Otitis Media. Arch Otolaryngol Head Neck Surg. 2003;129(10):1098–1100. doi:10.1001/archotol.129.10.1098
To evaluate if povidone-iodine (PVP-I) can be used topically in the treatment of chronic suppurative otitis media–tubotympanic disease and to compare it with ciprofloxacin hydrochloride ear drops.
Prospective double-blind randomized study.
Academic tertiary medical center.
Forty patients with chronic suppurative otitis media were randomized into 2 groups.
One group (19 patients) received 5% PVP-I ear drops, while the other group (21 patients) received 0.3% ciprofloxacin ear drops. Both were administered topically, 3 drops 3 times daily for 10 days. These patients were followed up at weekly intervals for up to 4 weeks after commencing therapy.
Clinical improvement at the end of study was 88% in the PVP-I group and 90% in the ciprofloxacin group. The most commonly isolated organism was Pseudomonas aeruginosa. In vitro resistance to ciprofloxacin was seen in 17% of organisms, while no resistance was seen for PVP-I.
To our knowledge, this is the first study to evaluate the efficacy of PVP-I as a topical agent in the treatment of chronic suppurative otitis media. The results show that clinically, topical PVP-I is as effective as topical ciprofloxacin, with a superior advantage of having no in vitro drug resistance. Also, there is an added benefit of reduced cost of therapy.
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