Association Between Cupular Deposits and Otosclerosis | Congenital Defects | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
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Original Article
December 2006

Association Between Cupular Deposits and Otosclerosis

Author Affiliations

Author Affiliations: Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis (Drs Hayashi, Cureoglu, Fukushima, and Paparella and Ms Schachern); International Hearing Foundation, Minneapolis (Drs Hayashi, Cureoglu, and Fukushima); Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan (Drs Hayashi and Sone); Department of Otorhinolaryngology, Dicle University, Medical School, Diyarbakir, Turkey (Dr Oktay); and Minnesota Ear, Head, and Neck Clinic, Minneapolis (Dr Paparella).

Arch Otolaryngol Head Neck Surg. 2006;132(12):1331-1334. doi:10.1001/archotol.132.12.1331
Abstract

Objective  To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis.

Design  Retrospective human temporal bone (TB) study. The incidence of cupular deposits in these 70 TBs was analyzed. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated.

Setting  Otolaryngology laboratory in a tertiary academic medical center.

Patients  The study material consisted of 35 human TBs with otosclerosis and 35 age-matched controls.

Main Outcome Measures  Morphometric evaluations of the incidence of cupular deposits, endosteal involvement of the otosclerotic focus, and stapedial fixation were made by light microscopy. Clinical records were reviewed retrospectively for clinical history of stapes surgery and prevalence of vestibular symptoms. The incidence of cupular deposits was compared between the otosclerotic and control groups. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated in the subjects with otosclerosis.

Results  The incidence of cupular deposits in TBs with otosclerosis was significantly higher than in those without whereas there was no correlation between the incidence of the deposits and dysequilibrium in cases of otosclerosis. An increase in deposits did not correlate with stapedial fixation, stapes surgery, or endosteal involvement.

Conclusions  Our results suggest otosclerosis as an underlying mechanism for the production of cupular deposits; however, we did not find an association between these deposits and vestibular symptoms.

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