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Article
February 1948

PROPHYLACTIC VALUE OF SULFATHIAZOLE: Art Experiment Designed to Test the Efficacy of Sulfathiazole Gum in Reducing the Bacterial Flora Causing Infectious Pharyngitis

Author Affiliations

CHICAGO
From the Department of Bacteriology and the Student Health Service of the Chicago Medical School.

Arch Otolaryngol. 1948;47(2):158-164. doi:10.1001/archotol.1948.00690030167008
Abstract

WITH the advent of the newer therapy for infectious diseases there has been an increase in the use of more or less specific drugs for prophylactic purposes. The idea of chemoprophylaxis is not a new one. There has been widespread use of quinine to prevent malaria and of certain silver preparations to prevent gonorrhea. However, it is only in recent years that sulfonamide drugs have been used to prevent the infectious diseases caused by hemolytic streptococci.1 The results have been attended with a good deal of success, especially those reported by the armed services. Under circumstances such as those occurring in large concentrations of men in camp units, diseases of the upper respiratory tract of all types find an optimal environment for expression. However, a question has been raised as to the expediency of using these methods in civilian populations.

The oropharyngeal route of invasion is commonly the one followed

References
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Harrison, J. W. E., and Rees, E. W.:  A Study of the Salivary Sulfathiazole Levels Produced by SulfathiazoleGum ,  Am. J. Pharm. 117:204, 1945.
8.
The sulfathiazole gum was supplied by White Laboratories, Inc., Newark, N. J.
9.
Leftwich, W. B.:  Intradermal Test for the Recognition of the Hypersensitivity to Sulfonamide Drugs ,  Bull. Johns Hopkins Hosp. 74:26, 1944.
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 Sulfadiazine Resistant Strains of Beta Hemolytic Streptococci, Epidemiology Unit no. 22 .  J. A. M. A. 129:921 ( (Dec. 1) ) 1945.
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