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February 1948

PROPHYLACTIC VALUE OF SULFATHIAZOLE: Art Experiment Designed to Test the Efficacy of Sulfathiazole Gum in Reducing the Bacterial Flora Causing Infectious Pharyngitis

Author Affiliations

From the Department of Bacteriology and the Student Health Service of the Chicago Medical School.

Arch Otolaryngol. 1948;47(2):158-164. doi:10.1001/archotol.1948.00690030167008

WITH the advent of the newer therapy for infectious diseases there has been an increase in the use of more or less specific drugs for prophylactic purposes. The idea of chemoprophylaxis is not a new one. There has been widespread use of quinine to prevent malaria and of certain silver preparations to prevent gonorrhea. However, it is only in recent years that sulfonamide drugs have been used to prevent the infectious diseases caused by hemolytic streptococci.1 The results have been attended with a good deal of success, especially those reported by the armed services. Under circumstances such as those occurring in large concentrations of men in camp units, diseases of the upper respiratory tract of all types find an optimal environment for expression. However, a question has been raised as to the expediency of using these methods in civilian populations.

The oropharyngeal route of invasion is commonly the one followed

Kuhns, D. M., and Feldman, H. A.:  Laboratory Methods Used in Determining Value of Sulfadiazine as a Mass Prophylactic Against Meningococci Infections ,  Am. J. Pub. Health 33:1461, 1943.Crossref
Coburn, A. V.:  Prevention of Respiratory Tract Bacterial Infections by Sulfadiazine Prophylaxis in United States Navy ,  J. A. M. A. 126:88 ( (Sept. 9) ) 1944.Crossref
Gooch, J. O., and Gorby, A. L.:  Use of Sulfathiazole as Prophylactic Agent ,  Mil. Surgeon 94:339, 1944.
Gettelman, E., and Kaiz, S. P.:  Treatment of Severe Tonsillitis in Naval Dispensary ,  U. S. Nav. M. Bull. 42:399, 1944.
Fox, N.; Kesel, R. G.; Neary, E. R., and Herbine, R. H.:  Effect of Sulfathiazole in Chewing Gum in Certain Oropharyngeal Infections ,  Arch. Otolaryng. 41:278 ( (April) ) 1945.Crossref
Fox, N., and Kesel, R. G.:  Hyperplastic Sinopharyngostomatitis ,  Arch. Otolaryng. 42:368 ( (Nov.) -Dec.) 1945.Crossref
Harrison, J. W. E., and Rees, E. W.:  A Study of the Salivary Sulfathiazole Levels Produced by SulfathiazoleGum ,  Am. J. Pharm. 117:204, 1945.
The sulfathiazole gum was supplied by White Laboratories, Inc., Newark, N. J.
Leftwich, W. B.:  Intradermal Test for the Recognition of the Hypersensitivity to Sulfonamide Drugs ,  Bull. Johns Hopkins Hosp. 74:26, 1944.
 Sulfadiazine Resistant Strains of Beta Hemolytic Streptococci, Epidemiology Unit no. 22 .  J. A. M. A. 129:921 ( (Dec. 1) ) 1945.