Customize your JAMA Network experience by selecting one or more topics from the list below.
Liberman PHP, Schultz C, Gomez MVSG, et al. Auditory Effects After Organ Preservation Protocol for Laryngeal/Hypopharyngeal Carcinomas. Arch Otolaryngol Head Neck Surg. 2004;130(11):1265–1268. doi:10.1001/archotol.130.11.1265
To investigate the prevalence of hearing loss after concomitant radiochemotherapy in patients enrolled in a larynx preservation protocol.
Consecutive patients treated in a tertiary cancer center hospital between 2001 and 2002.
Eligible subjects included patients prospectively enrolled in an organ preservation protocol based on concomitant radiotherapy and chemotherapy (cisplatin and paclitaxel).
Main Outcome Measures
Descriptive analysis of the results of audiologic evaluations, including pure-tone audiometry and immitance audiometry, which were performed prior to and 8 months after treatment. Change in hearing sensitivity was computed relative to baseline measures. Criteria to indicate hearing decrease after the treatment were defined as either a 20-dB decrease at any single test frequency or a 10-dB decrease at any 2 adjacent test frequencies.
A total of 11 patients were analyzed. Four patients (36%) had hearing loss after the treatment.
Our results suggest that the prevalence of hearing loss after radiochemotherapy in larynx preservation protocols is high (36%); however, it was usually mild and asymptomatic.
Create a personal account or sign in to: