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Branski RC, Sandulache VC, Dohar JE, Hebda PA. Mucosal Wound Healing in a Rabbit Model of Subglottic Stenosis: Biochemical Analysis of Secretions. Arch Otolaryngol Head Neck Surg. 2005;131(2):153–157. doi:10.1001/archotol.131.2.153
To build on work in laryngology and oral biology that suggests utility in the assay of secretions collected from wound sites as a predictive instrument to determine which infants will likely develop subglottic stenosis following endotracheal intubation and to document and describe the wound-healing process.
Prospective, randomized design.
Laser-induced subglottic injury was established in 3 rabbits. Secretions were collected from the subglottic region at 6 time points from days 4 to 21 following injury and from 4 uninjured control airways. The secretions were then subjected to enzyme-linked immunoassays for interleukin 1β and prostaglandin E2.
Three adult New Zealand white rabbits.
Main Outcome Measures
Interleukin 1β and prostaglandin E2 levels.
Measurable amounts of both mediators were obtained. Furthermore, different temporal patterns of expression were observed with interleukin 1β, showing increased levels on days 4 to 18, and with prostaglandin E2, showing increased levels on days 7 to 18. These results concur with emerging data regarding the role of each mediator in the wound-healing process.
Although in its infancy, the analysis of secretions collected from the site of injury in the subglottis may have utility in the management of patients following intubation-related trauma.
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