Acute Bacterial Rhinosinusitis Causes Hyperresponsiveness to Histamine Challenge in Mice | Allergy and Clinical Immunology | JAMA Otolaryngology–Head & Neck Surgery | JAMA Network
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1.
Walden  SMProud  DLichtenstein  LMKagey-Sobotka  ANaclerio  RM Antigen-provoked increase in histamine reactivity: observations on mechanisms.  Am Rev Respir Dis 1991;144642- 648PubMedGoogle ScholarCrossref
2.
Connell  JT Quantitative intranasal pollen challenges, 3: the priming effect in allergic rhinitis.  J Allergy 1969;4333- 44PubMedGoogle ScholarCrossref
3.
Gerth van Wijk  R Nasal hyperreactivity: its pathogenesis and clinical significance.  Clin Exp Allergy 1991;21661- 667PubMedGoogle ScholarCrossref
4.
Buckle  FGCohen  AB Nasal mucosal hyperpermeability to macromolecules in atopic rhinitis and extrinsic asthma.  J Allergy Clin Immunol 1975;55213- 221PubMedGoogle ScholarCrossref
5.
Konno  ATerada  NOkamoto  Y Changes of adrenergic and muscarinic cholinergic receptors in nasal mucosa in nasal allergy.  ORL J Otorhinolaryngol Relat Spec 1987;49103- 111PubMedGoogle ScholarCrossref
6.
Ishibe  TYamashita  TKumazawa  TTanaka  C Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy.  Arch Otorhinolaryngol 1983;238167- 173PubMedGoogle ScholarCrossref
7.
van Megen  YJKlaassen  ABRodrigues de Miranda  JFvan Ginneken  CAWentges  BT Alterations of muscarinic acetylcholine receptors in the nasal mucosa of allergic patients in comparison with nonallergic individuals.  J Allergy Clin Immunol 1991;87521- 529PubMedGoogle ScholarCrossref
8.
Kaliner  MA The late-phase reaction and its clinical implications.  Hosp Pract (Off Ed) 1987;2273- 83PubMedGoogle Scholar
9.
Bernstein  JM The role of autonomic nervous system and inflammatory mediators in nasal hyperreactivity: a review.  Otolaryngol Head Neck Surg 1991;105596- 607PubMedGoogle Scholar
10.
Numata  TKonno  AYamakoshi  THanazawa  TTerada  NNagata  H Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy.  Ann Otol Rhinol Laryngol 1999;108467- 473PubMedGoogle Scholar
11.
Mygind  N Mediators of nasal allergy.  J Allergy Clin Immunol 1982;70149- 159PubMedGoogle ScholarCrossref
12.
Clement  PAStoop  APKaufman  L Histamine threshold and nasal hyperreactivity in nonspecific allergic rhinopathy.  Rhinology 1985;2335- 42PubMedGoogle Scholar
13.
Gerth van Wijk  RDieges  PH Nasal hyper-responsiveness to histamine, methacholine and phentolamine in patients with perennial non-allergic rhinitis and in patients with infectious rhinitis.  Clin Otolaryngol Allied Sci 1991;16133- 137PubMedGoogle ScholarCrossref
14.
Sampaio  FLeopold  DProud  DMoylan  BTogias  A Determinants of the nasal secretory response to histamine in refractory rhinosinusitis [abstract].  J Allergy Clin Immunol 1998;101S46Google Scholar
15.
Imamura  TKambara  T Substance P as a potent stimulator of sneeze responses in experimental allergic rhinitis of guinea pigs.  Agents Actions 1992;37245- 249PubMedGoogle ScholarCrossref
16.
Saito  HHowie  KWattie  J  et al.  Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis.  Immunology 2001;104226- 234PubMedGoogle ScholarCrossref
17.
Blair  CNelson  MThompson  K  et al.  Allergic inflammation enhances bacterial sinusitis in mice.  J Allergy Clin Immunol 2001;108424- 429PubMedGoogle ScholarCrossref
18.
McCusker  CChicoine  MHamid  QMazer  B Site-specific sensitization in a murine model of allergic rhinitis: role of the upper airway in lower airways disease.  J Allergy Clin Immunol 2002;110891- 898PubMedGoogle ScholarCrossref
19.
Jeney  EVRaphael  GDMeredith  SDKaliner  MA Abnormal nasal glandular secretion in recurrent sinusitis.  J Allergy Clin Immunol 1990;8610- 18PubMedGoogle ScholarCrossref
20.
Igarashi  YSkoner  DPDoyle  WJWhite  MVFireman  PKaliner  MA Analysis of nasal secretions during experimental rhinovirus upper respiratory infections.  J Allergy Clin Immunol 1993;92722- 731PubMedGoogle ScholarCrossref
Original Article
October 2005

Acute Bacterial Rhinosinusitis Causes Hyperresponsiveness to Histamine Challenge in Mice

Author Affiliations

Author Affiliations: Department of Surgery, Section of Otolaryngology–Head and Neck Surgery, The University of Chicago Hospitals, Chicago, Ill (Drs Klemens, Kirtsreesakul, Luxameechanporn, and Naclerio); Department of Otolaryngology, Prince of Songkla University, Hat Yai, Songkla, Thailand (Dr Kirtsreesakul); and Department of Otolaryngology–Head and Neck Surgery, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (Dr Luxameechanporn).

Arch Otolaryngol Head Neck Surg. 2005;131(10):905-910. doi:10.1001/archotol.131.10.905
Abstract

Objectives  To develop a physiologic test of nasal responsiveness in mice and to evaluate whether mice with acute bacterial sinusitis develop nasal hyperresponsiveness.

Design  Several experimental studies will be described. The first was a titration pilot study. The second was a randomized, placebo-controlled study. The remainder were before-and-after trials.

Species  BALB/c or C57BL/6 mice.

Interventions  For these experiments, we exposed mice to histamine intranasally, then counted the number of sneezes and nose rubs as the primary outcome measure of nasal responsiveness. First, we constructed a dose-response curve. Second, we treated the mice with desloratadine, a histamine 1 receptor antagonist, prior to histamine exposure. Third, we challenged, with intranasal histamine, mice made allergic using 2 techniques. Fourth, we infected mice with Streptococcus pneumoniae to determine whether acute sinusitis causes nasal hyperresponsiveness to histamine exposure.

Results  Nasal histamine challenge led to a reproducible, dose-dependent increase in sneezing and nose rubs. The response to histamine exposure was blocked by desloratadine (P≤.05). Allergic mice had a significant increase in responsiveness (P≤.05) over baseline after exposure to antigen. Mice with acute sinusitis had a sustained increase in responsiveness, although less severe than after allergy, compared with baseline values that lasted 12 days after infection (P≤.05).

Conclusions  Nasal challenge with histamine is a physiologic test of nasal responsiveness. The hyperresponsiveness of allergic mice to histamine exposure parallels the response to nonspecific stimuli during the human allergic reaction. In addition, we showed that acute bacterial sinusitis causes nasal hyperresponsiveness in mice.

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