Early in poliomyelitis, before the onset of paralysis, or in those abortive cases which do not develop paralysis, there is found no pathognomonic diagnostic feature either at the bedside or in the laboratory. The clinical picture and history are usually fairly uniform and striking, but these same symptoms and signs are of such frequency in other infections that a reliable diagnosis cannot be made from them alone. The nearest evidence of a positive nature as to the presence of this infection in a preparalytic or abortive case is secured by the correlation of the clinical data with the results of examination of the cerebrospinal fluid.
The characteristics of cerebrospinal fluid in the early stages of poliomyelitis will be briefly summarized. It is clear and increased in amount. From 15 to 60 c.c. or more may be readily withdrawn. It frequently shows a marked web formation. The reduction of Fehling's solution
JEANS PC, JOHNSTON MR. THE CEREBROSPINAL FLUID IN POLIOMYELITIS: WITH ESPECIAL REFERENCE TO THE LANGE REACTION. Am J Dis Child. 1917;13(3):239–246. doi:10.1001/archpedi.1917.01910030036005
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