The clinical picture of chorea has never been more succinctly drawn than it was by Sydenham, who first described it as a clinical entity. Little was added to our conception of the disease until the middle of the nineteenth century, when the French clinicians made it a matter of particular study, and later German clinicians and Americans, especially Weir Mitchell and Osler, did much to separate the malady from similar nervous diseases. Later Osler was especially active in attempting to reach the etiology of the disease, together with Stephen Mac Kenzie he was instrumental in emphasizing the relation of chorea to manifestations of the group of symptoms then known as rheumatism, although as early as 1866 Germain See had insisted on this relationship. MacKenzie was able to relate less than 30 per cent, of his cases of chorea to rheumatism, and later observers, notably Morley Fletcher and Hughes, record similar
PORTER L. INTRATHECAL INJECTION OF HORSE SERUM IN THE TREATMENT OF CHOREA: A PRELIMINARY STUDY OF SEVEN TREATED CASES. Am J Dis Child. 1918;16(2):109–117. doi:10.1001/archpedi.1918.01910140048005
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