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September 1919


Author Affiliations

From the Department of Pediatrics, Washington University School of Medicine.

Am J Dis Child. 1919;18(3):173-178. doi:10.1001/archpedi.1919.04110330023003

In this paper it is intended to show that contrary to most current opinion, involvement of the central nervous system in hereditary syphilis is relatively common, and that by statistical study there is no difference in the incidence of central nervous involvement in hereditary and in acquired syphilis. It is further emphasized that the treatment for neurosyphilis is the same and should be carried out just as intensively whether the infection is acquired or hereditary. As a matter of fact, the differences between hereditary and acquired syphilis are accounted for by the fact that in one case it occurs in a rapidly developing organism and in the other case in a mature organism.

There have appeared in the last few years a number of studies of the incidence of cerebrospinal involvement in acquired syphilis based on the examination of the cerebrospinal fluid. Most of these studies have been made on

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