During the summer of 1918 we made an effort to secure some exact clinical data on the effects of introduction of fluids in the case of dehydrated infants. This work was started with the idea of using only the peritoneal route as described by Blackfan.1 Preliminary to the introduction of his method into routine use, we made a number of intraperitoneal injections in a series of six rabbits. Sixty c.c. of 6 per cent, dextrose solution was used in one group of three rabbits and 60 c.c. of 4 per cent. sodium bicarbonate solution was used in another group of three rabbits. Careful records were kept of the animals after treatment, as to temperature, activity, appetite, etc. In three rabbits we used a solution of 6 per cent. dextrose combined with 4 per cent, sodium bicarbonate. The six animals received forty injections in all. There was one death. This
McLEAN S, LANG CA. FLUID INJECTIONS IN DEHYDRATED INFANTS. Am J Dis Child. 1920;19(5):359–369. doi:10.1001/archpedi.1920.01910230029005
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