Although the midbrain is one of the smallest divisions of the central nervous system, within its structure are to be found certain essential nuclear centers and great nerve paths, motor and sensory, connecting the cerebrum and cerebellum with the spinal cord and thence with the entire nervous system. It is the continuation upward from the pons varioli and comprises the two crura of the cerebrum which are surmounted by two pairs of tubercles; the corpora quadrigemina. The aqueduct of Sylvius, connecting the third and fourth ventricles, penetrates its entire length on its dorsal aspect.
Its principal nuclear structures, in addition to the quadrigeminal bodies, are the two large paired red nuclei, receiving fibers from the superior cerebellar peduncles, the nuclei of the third and fourth cranial nerves, the central gray nuclei, the small nuclei of the fifth nerve, the nuclei of the posterior commissure of the posterior longitudinal bundles and
KNOX JHM. LESIONS IN THE MIDBRAIN: REPORT OF A CASE. Am J Dis Child. 1920;20(5):436–444. doi:10.1001/archpedi.1920.01910290098005
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