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May 1921


Author Affiliations

Adjunct Pediatrician, Lebanon Hospital; Medical Director, Israel Orphan Asylum NEW YORK

Am J Dis Child. 1921;21(5):472-476. doi:10.1001/archpedi.1921.01910350059007

My object in reporting these cases is to have on record the fact that diphtheria can occur among children who possess either natural immunity or who have been immunized by the toxin-antitoxin procedure. If we are to utilize our knowledge of diphtheria immunity intelligently, without prejudice to the community or to the child who has suspicious sore throat, and raise the bars of precautions against a disease of so many possibilities, we must be sure that our interpretative value of a negative Schick reaction will stand the test of time and experience, and particularly that immunity, as obtained by the toxin-antitoxin instillation, is sufficiently universal in its application that not even an occasional exception will alter its value. An immunity recorded by a negative Schick reaction should not be sufficient, and only when a sufficient number of Schick negative immunized children have been exposed to diphtheria contagion and have escaped

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