Although orthostatic albuminuria has been the subject of frequent investigation, the pathology of the condition is far from being clearly understood. There are various opinions as to the cause and the etiologic importance of the appearance of albuminuria.
Albuminuria is much more common in children than in adults. The urine which is secreted while the individual is in a lying posture usually presents nothing abnormal. But, as is assumed by observers and as I have also found, albuminuria does not necessarily appear in the upright position. The same individual excretes urine with a large amount of albumin one day, while it contains none the next day, and even the same day the contents and the appearance of albumin in the urine are variable. Pavy was the first to term this condition cyclic albuminuria.
As to the cause of the albuminuria, Jehle1 believes that it is due to a venous
SAITO H. CLINICAL INVESTIGATIONS ON ORTHOSTATIC ALBUMINURIA. Am J Dis Child. 1921;22(4):388–401. doi:10.1001/archpedi.1921.04120040063006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.