All those who treat infants and young children encounter with more or less frequency instances in which the diapers after having been wet with urine for several hours give off the odor of ammonia. Frequently the odor is faint and the condition occurs in infants otherwise well and thriving. In some cases the ammoniacal odor is very pronounced and accompanied by irritation of the skin of the diaper region usually more marked over the buttocks and inner surfaces of the thighs. The lesion may consist only of diffuse redness but not infrequently vesicles and papules with more or less excoriation occur. There seems no doubt that the dermatitis is caused directly by the ammonia. Attention was called to the condition by Southworth1 and it has been discussed in some detail by Zahorsky2 and more recently by Brennemann.3 The latter observer has described especally the ulceration at the
COOKE JV. THE ETIOLOGY AND TREATMENT OF AMMONIA DERMATITIS OF THE GLUTEAL REGION OF INFANTS. Am J Dis Child. 1921;22(5):481–492. doi:10.1001/archpedi.1921.04120050052008
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