In 1916 Johnston1 reported on the use of the colloidal gold test on the spinal fluid in four cases of poliomyelitis. He found an early transitory reaction in the syphilitic zone during the acute stage, and he considered that the test might prove an important aid in diagnosis. In March, 1917, Felton and Maxcy2 published an excellent and important contribution on the subject. These investigators examined the spinal fluids of fifty-seven patients during various stages of the disease, and came to the following conclusions: (1) In the acute stage of poliomyelitis, the spinal fluid reacts with colloidal gold in dilutions of 1:40 to 1:60 producing a maximum decoloration of 3. (2) In the second and third weeks the reaction is practically the same, with a tendency to clear up in some cases and a precipitation in higher dilutions in others. (3) From the fourth to the eighth week,
REGAN JC, CHENEY GWH. THE VALUE OF THE ROUTINE USE OF THE COLLOIDAL GOLD REACTION IN ACUTE EPIDEMIC POLIOMYELITIS. Am J Dis Child. 1922;23(2):107–123. doi:10.1001/archpedi.1922.01910380018002
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