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Progress in Pediatrics
February 1922


Am J Dis Child. 1922;23(2):146-182. doi:10.1001/archpedi.1922.01910380057007

MODE OF INFECTION  J. W. Allan1 is of the opinion that antenatal tuberculosis is more common than is generally believed and that many children are born with "seeds" of the disease lying latent which at a later period of life give rise to manifest tuberculosis. He thinks the placenta offers the most likely portal of entry for the tubercle bacillus, and quotes Bonny, who says that, despite the normal appearance of the fetal organ and of the placenta, tuberculosis has resulted from inoculation of animals with portions of these tissues and with blood from the placental circulation. Allan thinks that to account for the subseqent development of tuberculosis in the animals inoculated these apparently healthy tissues must have contained some "seed" or inverted form of the tubercle bacillus.M. Dubois2 adds the report of a case of intrauterine tuberculous infection to those already found in the literature. A