Considerable research has been conducted recently, investigating the influence of the alkali phosphates, especially sodium and potassium diortho-phosphates, on normal and spasmophilic infants. Binger1 produced tetany by the intravenous injection of ortho-phosphates. Howland and Marriott2 found that when the inorganic phosphorus of the serum was high in severe nephritis that the calcium of the serum was greatly diminished. They considered the question, therefore, whether there was a sufficient accumulation of inorganic phosphates in the serum in tetany to account for the reduction of the calcium. Their determinations in cases of active tetany showed a low calcium content in the blood serum but no significant increase in phosphorus. Kramer, Tisdall and Howland2a have very recently confirmed this work and state that an increase in the inorganic phosphorus of the serum does not seem to be responsible for infantile tetany, although in cases of rickets complicated by tetany there
CALVIN JK, BOROVSKY MP. RESULTS FOLLOWING THE ADMINISTRATION OF ALKALI PHOSPHATES TO SPASMOPHILIC, RACHITIC AND NORMAL INFANTS. Am J Dis Child. 1922;23(3):238–242. doi:10.1001/archpedi.1922.01910390057004
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