In this discussion, we are not concerned with the controversy as to whether the cutaneous sensitization observed clinically in eczema, urticaria papulosa and angioneurotic edema in infants and children is a phenomenon of anaphylaxis or a state of allergy. We believe that the question will be settled when the mechanism of protein sensitization is more definitely known. However, the fact remains that local cutaneous reactions are brought to light when various proteins are applied by cutaneous or intracutaneous tests to the skin of patients who are subjects of the diseases mentioned. The results indicate that these cutaneous reactions depend on a protein substance which is the essential cause of the efflorescence in a comparatively large number of cases. Moreover, the cause of the disease having been determined, with intelligent cooperation on the part of the parents of the patient in regard to diet, the clinical cure far surpasses the results
SIDLICK DM, KNOWLES FC. THE VALUE OF CUTANEOUS SENSITIZATION TESTS EMPLOYED IN ECZEMA AND PAPULAR URTICARIA OF CHILDHOOD. Am J Dis Child. 1922;23(4):316–322. doi:10.1001/archpedi.1922.01910400036003
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