The pathology of congenital hypertrophic pyloric stenosis is definitely known. The pathologic physiology is still a matter of dispute. Some believe that the symptoms are due to the mechanical obstruction of the tumor itself. Others hold that spasm is responsible for the manifestations of this condition. Both factors probably are operative. Whatever view is held, the picture of pyloric stenosis is easily explained. Narrowing of the pylours, anatomic, spastic, or both, obstructs the passage of food from the stomach. All the symptoms may be referred to that single fact. In order to force the contents beyond the pylorus, gastric peristalsis is exaggerated. This proceeds until the waves show through the abdominal wall running from cardia to pylorus. Visibility of the contractions is enhanced by the diminished tone and atrophy of the musculature of the abdominal wall, due to the virtual starvation which accompanies the condition. The pyloric tumor may be
TUMPEER IH, BERNSTEIN MA. EXPERIMENTAL PYLORIC STENOSIS. Am J Dis Child. 1922;24(4):306–310. doi:10.1001/archpedi.1922.04120100039004
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