The question of transference of antibodies, protein sensitization and infection, from mother to child has been studied much. Numerous investigators at various times have worked intensively on this subject.
The most easily proved transference of immune bodies occurs in the case of the well known immunity to diphtheria, which is present in a high percentage of new-born infants. This may be investigated either by examination of the cord blood serum, or by the intradermal toxin test (Schick test).
The most intensive studies on the diphtheria antitoxin content in mother and new-born that we have been able to find were made by von Groer and Kassowitz.1 They made quantitative estimation on the antitoxin content of umbilical cord blood serum in 143 new-born infants, and compared these results with like estimation made on the blood serum of the mothers. They also did intradermal toxin injections in all of these patients, and
RUH HO, McCLELLAND JE. COMPARISON OF DIPHTHERIA IMMUNITY IN THE MOTHER AND IN THE NEW-BORN. Am J Dis Child. 1923;25(1):59–62. doi:10.1001/archpedi.1923.01920010064004
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