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February 1924


Am J Dis Child. 1924;27(2):192-194. doi:10.1001/archpedi.1924.01920080099008

Acute hemorrhagic pancreatitis in childhood is a rare disease. The case which is here reported is the only one that has been known to occur in the medical and surgical practice of the Hospital for Sick Children in a period of forty years. The reason for this rarity is evident when one considers that the conditions to which pancreatitis is usually attributed, such as gallstones and cholecystitis, are diseases of adult life.

The manner in which these conditions give rise to pancreatitis, or more specifically, cause trypsinogen of the pancreas to be converted into trypsin before it reaches the intestinal canal has been the subject of much investigation. It seems probable that the release of trypsin in the pancreas may be brought about by the introduction of either bacterial infection, through the lymphatics, blood stream or the pancreatic ducts, or of bile or duodenal juices, as the result of abnormal