In the course of routine cutaneous tests with tuberculin in children, it was observed that lymphangitis developed in certain instances. This local manifestation varied in severity and extent and was accompanied by constitutional reactions.1 Within from twenty-four to forty-eight hours after the cutaneous test, a streak of lymphangitis developed in relation to the positive local reaction as an extension along the lymph channels of the forearm. The possibility of faulty technic was excluded by rigid aseptic precautions at all stages of the test and by sterility of the tuberculins which were used. The significance of the phenomenon became apparent later from a supplementary study of the clinical, physical and roentgen-ray findings, and these observations suggest that lymphangitis occurring with cutaneous tuberculin tests in children is pathognomonic of tuberculosis with an active focus of glandular origin. In a series of cases of adult tuberculosis, the same observations confirmed the relation
EBERSON F. STUDIES IN TUBERCULOSIS: IV. SIGNIFICANCE OF LYMPHANGITIS OCCURRING WITH CUTANEOUS TUBERCULIN TESTS IN CHILDREN. Am J Dis Child. 1925;29(1):29–40. doi:10.1001/archpedi.1925.04120250032002
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