The good results repeatedly reported, obtained by changing the reaction of the urine in the treatment of pyelitis in infancy and childhood, led us to undertake a series of experiments to determine the effect of change of reaction on the growth of colon bacillus and staphylococcus. The work of numerous investigators has shown that the limits of the acidity and alkalinity of the urine are insufficient to check the growth of the colon bacillus. Shohl and Janney1 found that the most rapid growth occurred between hydrogen-ion concentrations 6 and 7, and that at 5.4 and 8.4 the rate of growth was about the same. Growth was inhibited at the acid limit between 4.6 and 5, and at the alkaline limit between 9.2 and 9.6. The death point for bacteria is very near the inhibition point of growth. The authors noticed that for four hours there was no increase in
HELMHOLZ HF, MILLIKIN F. THE EFFECT OF CHANGE OF REACTION ON THE GROWTH OF BACILLUS COLI AND STAPHYLOCOCCUS AUREUS. Am J Dis Child. 1925;29(1):78–85. doi:10.1001/archpedi.1925.04120250081008
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